Response to influenza immunization in patients with common variable immunodeficiency
نویسندگان
چکیده
Results Both the CVID and controls showed similar induction of flu-specific IgM-secreting memory B cells after vaccination. Before vaccination, CVID subjects had significantly lower frequencies of flu-specific IgG and IgA memory B cells. Half of the CVID subjects (4/8) showed an increase in flu-specific IgG-secreting memory B cells post vaccination, whereas the other half showed none. 8/8 controls showed increased flu-specific IgG-secreting memory B cells post-vaccination. None of the CVID subjects developed flu-specific IgA memory B cells post vaccination, compared to 5/8 normal subjects.
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